Invasive Fractional Flow Reserve (FFR)
Fractional Flow Reserve is measured during invasive coronary angiography by placing a pressure measuring guide wire directly in the coronary artery while adenosine (a pharmacologic agent used to increase coronary blood flow) is administered to the patient. The ratio of the blood pressure in the diseased vessel to the blood pressure in the aorta at the origin of the coronary artery is the FFR value.
FFR has been recognized by the European Society of Cardiology as the gold standard (Class Ia data) for guiding treatment for coronary artery disease1. FFR assesses the impact of each coronary lesion on the blood flow in the coronary artery. Measurement of FFR allows physicians to identify which lesions are causing ischemia, providing valuable information that helps determine if a patient requires an interventional procedure. Studies have shown that treatment guided by FFR data results in improved clinical outcomes, including a significantly reduced risk of death or major cardiac event, and substantially lower healthcare costs2,3.
HeartFlow’s Non-Invasive FFRCT
HeartFlow’s innovative FFRCT technology enables the non-invasive computation of Fractional Flow Reserve (FFRCT). HeartFlow’s analysis of cardiac CT scan data can determine blood pressure and blood flow throughout the coronary tree and allows computation of FFRCT non-invasively. FFRCT analysis requires no additional patient procedures. CT scan data and FFRCT results are transmitted via HeartFlow’s secure web interface. Results are provided as an interactive report that can be easily interrogated by the physician to provide lesion-specific FFRCT values.
Initial clinical data have shown a good correlation (r value of 0.73) between non-invasive FFRCT and invasive FFR measurements3. We have a strong commitment to continued clinical research and towards supporting our novel technology with high quality data.
The HeartFlow Process
*Demo- Functionality not yet implemented.
1. Wijns W et al. EHJ. 2010 2. Kushner FG et al. JACC. 2009 3. Min JK et al. JACC 2011
Note: Information presented within the Invasive Fractional Flow Reserve (FFR) section above relates to the invasive measurement of FFR and does not relate to current HeartFlow products.